Any thoughts on the next “uninsurable” trend in P&C?

As a commercial UW of 11 years for one of the majors in the casualty space, I’ve sat on dozens of calls talking about the next big thing that’s going to wreck havoc on our P&L. Some are corporate fear mongering and politics to appease the overlords, and some are real and manifest substantial exposure to loss. From Lead, Asbestos, MTBE, PCBs, Formaldehyde, Fungi, Nuclear, Silica, PFAS, Cyber, Food Coloring, etc etc etc, any thoughts on the next ISO or exclusion? Or your favorite in general?