What are some major misprints on main game board you've run into? (Inspired by AllPlay's Through the Desert)

So, as I was awaiting my Through the Desert arrival, I checked up on the KS page and looksy looksy – apparently the main board has a misprint of arguable significance (a water spot which is used for scoring). Haven't really run into this so much yet (last time I saw this was in Root's Riverfolk first printing where Lizard Cult had a fairly major misprint on their board for scoring).

So what other games have ruined a whole print run with misprints, be it functional or aesthetic? What have publishers done to rectify it?